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Tadalafil
Tadalafil is the active ingredient in medicines used to treat erectile dysfunction in adult men, and in some cases the symptoms of benign prostatic hyperplasia (an enlarged prostate). It belongs to a class of medicines called phosphodiesterase type 5 (PDE5) inhibitors. It is the generic equivalent of the originally branded medicine Cialis — for that reason it's often searched for as generic Cialis. It helps men who have difficulty getting or keeping an erection suitable for sexual activity.
Reviewed by the Kamagra AUS Pharmacy Team on 5 September 2026 · Next review June 2027
Sources for the medical information on this page
- Healthdirect Australia — Tadalafil — Australian guidance on medicines and health conditions — search "tadalafil" for current advice.
- PDE5 Inhibitors — StatPearls, NCBI Bookshelf — Peer-reviewed clinical pharmacology of the whole drug class.
- TGA — Tadalafil product information — Therapeutic Goods Administration — search the TGA's Product Information / ARTG for tadalafil-based products.
Tadalafil medicines we deliver Australia-wide
Browse the full Erectile Dysfunction range7 generic Tadalafil products — same molecule, different brands, formats and pack sizes.
About Tadalafil
How it works
Tadalafil blocks the PDE5 enzyme, allowing cyclic guanosine monophosphate (cGMP) to build up and the blood vessels in the penis to relax, which improves blood flow during sexual stimulation. As with other PDE5 inhibitors, sexual arousal is required for it to work. A notable feature of tadalafil is its long duration of action, which can extend up to around 36 hours and has led to it sometimes being referred to as the 'weekend' treatment. It generally takes effect within roughly half an hour to an hour.
How it is taken
Tadalafil is taken by mouth, either before anticipated sexual activity or, in some cases, as a low daily dose, at the dose advised by your doctor. It can be taken with or without food, and unlike some similar medicines its effect is not strongly influenced by meals. Always follow the patient information leaflet and the advice of your doctor or pharmacist.
Side effects
Common (usually mild and temporary):
- Headache
- Flushing
- Indigestion
- Back pain
- Muscle aches
- Nasal congestion
Stop and seek medical help if you experience:
- A painful erection lasting longer than 4 hours (priapism) — seek urgent medical help
- Sudden loss or decrease in vision in one or both eyes
- Sudden loss or reduction in hearing, sometimes with ringing in the ears
- Chest pain during or after sexual activity
- Signs of a serious allergic reaction such as swelling of the face, lips or throat, rash or difficulty breathing
Safety & who should not take it
- Must NOT be taken with nitrate medicines for angina or with nitric-oxide donors such as 'poppers', because of the risk of a serious fall in blood pressure.
- Use with caution if you have heart or blood-vessel disease, or if your doctor has advised against sexual activity.
- Tell your doctor about any liver or kidney problems, as the dose may need to be adjusted.
- Caution is needed with low blood pressure and with alpha-blockers or other blood-pressure-lowering medicines.
- Alcohol can add to a lowering of blood pressure and may cause dizziness.
- Grapefruit and grapefruit juice may affect how the medicine works and are best avoided.
- Not intended for use by women, children or anyone under 18 years of age.
Storage
Store in the original packaging at room temperature, out of the sight and reach of children, and do not use after the expiry date.
Frequently asked questions
Why is tadalafil sometimes called the 'weekend' treatment?
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Its effect can last for up to around 36 hours, which is longer than several other erectile-dysfunction medicines, allowing more flexibility over timing. The leaflet provides further detail on duration.
Does food affect tadalafil?
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Its effect is generally not strongly affected by food, so it can be taken with or without a meal. Your doctor or pharmacist can give tailored advice.
How is tadalafil different from Cialis?
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Cialis is the original brand under which tadalafil was launched; a generic version contains the identical active substance and dose, so its effect and duration are the same.
How much does tadalafil cost in Australia?
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Generic tadalafil 20mg starts from $80.05 for a 20-pack (Vidalista 20mg), with a lower per-tablet price on larger packs. Delivery is free on orders over $150, otherwise $20 flat.
More questions answered: Vidalista, tadalafil & Cialis (5 answers)
Important: This information is general and not a substitute for medical advice. Always read the patient information leaflet supplied with your medicine and consult a doctor or pharmacist before use — especially if you have existing health conditions or take other medication.
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